Examining the Nootropic Effects of KeenMind on Human Cognitive Functioning: 90 day Double-Blind Placebo-Controlled Randomized Trial*

Abstract: While Ayurvedic medicine has touted the cognitive enhancing effects of Bacopa monnieri for centuries, there is a need for double-blind placebo-controlled investigations.

Methods: One hundred and seven healthy participants aged between 18 and 60 years were recruited for this double-blind placebo-controlled independent group design investigation. Sixty-two participants completed the study with 80% treatment compliance. Neuropsychological testing using the Cognitive Drug Research cognitive assessment system was conducted at baseline and after 90 days of treatment with KeenMind (2 capsules) or placebo.

Results: KeenMind significantly improved performance on the ‘Working Memory’ factor, more specifically spatial working memory accuracy. The number of false-positives recorded in the Rapid visual information processing task was also reduced for the KeenMind group following the treatment period.

Conclusions: This study provides support for previous studies reporting cognitive enhancing effects in healthy humans after a 90 day administration of KeenMind. Although there were several tasks that were not significantly improved by KeenMind, many of the statistical analyses trended towards an improvement in cognitive functioning in areas of attention, working memory and psychomotor tasks. This study provides evidence that 90 day KeenMind treatment improves accuracy in more complex cognitive tasks.

*Stough C et al. 2008. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother. Res., 22: 1629-1634.

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